Anti-p200 Pemphigoid: The First Case Report in Hong Kong

Fung Ning

This is the first reported case of anti-p200 pemphigoid in Hong Kong. An elderly gentleman presented with a progressive bullous disease affecting the skin, eyes, oral cavity and genital mucosa over two months. Histopathological examination and direct immunofluorescence initially suggested a diagnosis of bullous pemphigoid. Immunoblot tests confirmed positivity for anti-p200 and negativity for autoantibodies linked to other subepidermal autoimmune bullous diseases. Anti-p200 pemphigoid is often misdiagnosed as various other autoimmune bullous diseases. A high index of clinical suspicion and access to autoantibody testing are essential for accurate diagnosis and effective management of this rare disorder.

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